The vast majority of proteins are believed to have one specific function. Throughout the
course of evolution, however, some proteins have acquired additional functions to meet the …

The Siah ubiquitin ligases are members of the RING finger E3 ligases. The Siah E3s are
conserved from fly to mammals. Primarily implicated in cellular stress responses, Siah …

The delicate balance between the synthesis and the degradation of proteins ensures
cellular homeostasis. Proteases act in an irreversible manner and therefore have to be …

Background Dysregulation of eukaryotic translation elongation factor 1 delta (EEF1D) in
cancers has been reported; however, the role and mechanisms of EEF1D in osteosarcoma …

Protein–protein interaction occurs transiently or stably when two or more proteins bind
together to mediate a wide range of cellular processes such as protein modification, signal …

Background The constituents of stable multiprotein complexes are known to dissociate from
the complex to play independent regulatory roles. The components of translation elongation …

Abstract The Siah1 and Siah2 ubiquitin ligases are implicated in diverse biological
processes ranging from cellular stress responses, signaling to transcriptional regulation. A …

Colorectal cancer (CRC) is the third most common cancer and causes high mortality
worldwide. Although CRC has been studied widely, the molecular mechanism is not …

Objective The purpose of this paper was to investigate the role and mechanism of EEF1D in
various diseases, especially in tumorigenesis and development, and explore the possibility …

The human translation machinery includes three types of supramolecular complexes
involved in elongation of the polypeptide chain: the ribosome, complex of elongation factors …