Applications of bioluminescence in biotechnology and beyond

AJ Syed, JC Anderson - Chemical Society Reviews, 2021 - pubs.rsc.org
Bioluminescence is the fascinating natural phenomenon by which living creatures produce
light. Bioluminescence occurs when the oxidation of a small-molecule luciferin is catalysed …

Chemi-and bioluminescence of cyclic peroxides

M Vacher, I Fdez. Galván, BW Ding, S Schramm… - Chemical …, 2018 - ACS Publications
Bioluminescence is a phenomenon that has fascinated mankind for centuries. Today the
phenomenon and its sibling, chemiluminescence, have impacted society with a number of …

Opening a gateway for chemiluminescence cell imaging: distinctive methodology for design of bright chemiluminescent dioxetane probes

O Green, T Eilon, N Hananya, S Gutkin… - ACS central …, 2017 - ACS Publications
Chemiluminescence probes are considered to be among the most sensitive diagnostic tools
that provide high signal-to-noise ratio for various applications such as DNA detection and …

Seeing (and using) the light: recent developments in bioluminescence technology

AC Love, JA Prescher - Cell Chemical Biology, 2020 - cell.com
Bioluminescence has long been used to image biological processes in vivo. This technology
features luciferase enzymes and luciferin small molecules that produce visible light …

Unprecedented sensitivity in a probe for monitoring cathepsin B: chemiluminescence microscopy cell‐imaging of a natively expressed enzyme

ME Roth‐Konforti, CR Bauer… - Angewandte Chemie …, 2017 - Wiley Online Library
Until recently, chemiluminescence cell images could only be obtained using luciferase‐
activated probes. Moreover, chemiluminescence microscopy cell‐imaging has not been …

Orthogonal luciferase–luciferin pairs for bioluminescence imaging

KA Jones, WB Porterfield, CM Rathbun… - Journal of the …, 2017 - ACS Publications
Bioluminescence imaging with luciferase–luciferin pairs is widely used in biomedical
research. Several luciferases have been identified in nature, and many have been adapted …

Recent achievements of bioluminescence imaging based on firefly luciferin-luciferase system

S Li, Z Ruan, H Zhang, H Xu - European Journal of Medicinal Chemistry, 2021 - Elsevier
Bioluminescence imaging (BLI) is a newly developed noninvasive visual approach which
facilitates the understanding of a plethora of biological processes in vitro and in vivo due to …

Modular Access to Diverse Chemiluminescent Dioxetane‐Luminophores through Convergent Synthesis

S Gnaim, SP Gholap, L Ge, S Das… - Angewandte Chemie …, 2022 - Wiley Online Library
Adamantyl‐dioxetane luminophores are an important class of chemiluminescent molecular
probes for diagnostics and imaging. We have developed a new efficient synthetic route for …

Multiplexed bioluminescence microscopy via phasor analysis

Z Yao, CK Brennan, L Scipioni, H Chen, KK Ng… - Nature …, 2022 - nature.com
Bioluminescence imaging with luciferase–luciferin pairs is a well-established technique for
visualizing biological processes across tissues and whole organisms. Applications at the …

Luciferin synthesis and pesticide detection by luminescence enzymatic cascades

P Watthaisong, P Kamutira… - Angewandte Chemie …, 2022 - Wiley Online Library
Abstract D‐Luciferin (D‐LH2), a substrate of firefly luciferase (Fluc), is important for a wide
range of bioluminescence applications. This work reports a new and green method using …