Recent advances in mass spectrometric analysis of glycoproteins

A Banazadeh, L Veillon, KM Wooding… - …, 2017 - Wiley Online Library
Glycosylation is one of the most common posttranslational modifications of proteins that
plays essential roles in various biological processes, including protein folding, host …

Identifying N-Glycan Biomarkers in Colorectal Cancer by Mass Spectrometry

MK Sethi, WS Hancock, S Fanayan - Accounts of chemical …, 2016 - ACS Publications
Conspectus Colorectal cancer (CRC) is one of the most prevalent cancers worldwide.
Delineating biological markers (biomarkers) for early detection, when treatment is most …

Clinical application of quantitative glycomics

W Peng, J Zhao, X Dong, A Banazadeh… - Expert review of …, 2018 - Taylor & Francis
Introduction: Aberrant glycosylation has been associated with many diseases. Decades of
research activities have reported many reliable glycan biomarkers of different diseases …

NEGATIVE ION MASS SPECTROMETRY FOR THE ANALYSIS OF N‐LINKED GLYCANS

DJ Harvey - Mass Spectrometry Reviews, 2020 - Wiley Online Library
N‐glycans from glycoproteins are complex, branched structures whose structural
determination presents many analytical problems. Mass spectrometry, usually conducted in …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: an update for 2015–2016

DJ Harvey - Mass Spectrometry Reviews, 2021 - Wiley Online Library
This review is the ninth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of …

GALNT8 suppresses breast cancer cell metastasis potential by regulating EGFR O-GalNAcylation

T Huang, F Meng, H Huang, L Wang, L Wang… - Biochemical and …, 2022 - Elsevier
Breast cancer represents the most lethal malignancy that threatens the health of females.
Metastasis is the fatal hallmark of breast cancer, and current effective therapeutic targets of …

[HTML][HTML] Utilizing multimodal mass spectrometry imaging for profiling immune cell composition and N-glycosylation across colorectal carcinoma disease progression

LEA Young, PJ Nietert, R Stubler, CG Kittrell… - Frontiers in …, 2024 - frontiersin.org
Colorectal cancer (CRC) stands as a leading cause of death worldwide, often arising from
specific genetic mutations, progressing from pre-cancerous adenomas to adenocarcinomas …

Altered N-linked glycosylation in endometrial cancer

P Mittal, M Briggs, M Klingler-Hoffmann, G Kaur… - Analytical and …, 2021 - Springer
It is well established that cell surface glycans play a vital role in biological processes and
their altered form can lead to carcinogenesis. Mass spectrometry–based techniques have …

[HTML][HTML] Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment

S Theivendran, J Tang, C Lei, Y Yang, H Song… - Chemical …, 2020 - pubs.rsc.org
Post translational modifications (PTM) such as phosphorylation are often correlated with
tumorigenesis and malignancy in breast cancer. Herein, we report a PTM-assisted strategy …

Triple-internal standard based glycan structural assignment method for capillary electrophoresis analysis of carbohydrates

G Jarvas, M Szigeti, J Chapman, A Guttman - Analytical chemistry, 2016 - ACS Publications
Despite the ever growing use of capillary electrophoresis in biomedical research and the
biopharmaceutical industry, the development of data interpretation methods is lagging …