Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer's disease
During recent years, the preclinical stage of Alzheimer's disease (AD) has become a major
focus of research. Continued failures in clinical trials and the realization that early …
focus of research. Continued failures in clinical trials and the realization that early …
Alzheimer's disease: from firing instability to homeostasis network collapse
S Frere, I Slutsky - Neuron, 2018 - cell.com
Alzheimer's disease (AD) starts from pure cognitive impairments and gradually progresses
into degeneration of specific brain circuits. Although numerous factors initiating AD have …
into degeneration of specific brain circuits. Although numerous factors initiating AD have …
Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission
HC Rice, D De Malmazet, A Schreurs, S Frere… - Science, 2019 - science.org
INTRODUCTION More than 30 years have passed since the amyloid-β precursor protein
(APP) was identified. Although the role of APP in Alzheimer's disease has been studied …
(APP) was identified. Although the role of APP in Alzheimer's disease has been studied …
Organization and functions of mGlu and GABAB receptor complexes
The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals
by activating fast-acting ligand-gated ion channels and more slowly acting G-protein …
by activating fast-acting ligand-gated ion channels and more slowly acting G-protein …
Role of GABAB receptors in learning and memory and neurological disorders
Although it is evident from the literature that altered GABA B receptor function does affect
behavior, these results often do not correspond well. These differences could be due to the …
behavior, these results often do not correspond well. These differences could be due to the …
Human brain-derived Aβ oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP
Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's
disease (AD) and several theories have been advanced to explain the relationship. A …
disease (AD) and several theories have been advanced to explain the relationship. A …
Mitochondrial regulation of the hippocampal firing rate set point and seizure susceptibility
Maintaining average activity within a set-point range constitutes a fundamental property of
central neural circuits. However, whether and how activity set points are regulated remains …
central neural circuits. However, whether and how activity set points are regulated remains …
Classics in chemical neuroscience: baclofen
CN Kent, C Park, CW Lindsley - ACS chemical neuroscience, 2020 - ACS Publications
Baclofen, β-(4-chlorophenyl)-γ-aminobutyric acid, holds a unique position in neuroscience,
remaining the only US Food and Drug Administration (FDA) approved GABAB agonist …
remaining the only US Food and Drug Administration (FDA) approved GABAB agonist …
Keeping the Balance: GABAB Receptors in the Developing Brain and Beyond
D Bassetti - Brain Sciences, 2022 - mdpi.com
The main neurotransmitter in the brain responsible for the inhibition of neuronal activity is γ-
aminobutyric acid (GABA). It plays a crucial role in circuit formation during development …
aminobutyric acid (GABA). It plays a crucial role in circuit formation during development …
Assessment of spontaneous neuronal activity in vitro using multi-well multi-electrode arrays: implications for assay development
Multi-electrode arrays (MEAs) are being more widely used by researchers as an instrument
platform for monitoring prolonged, non-destructive recordings of spontaneously firing …
platform for monitoring prolonged, non-destructive recordings of spontaneously firing …