Chalcones are bioactive molecules of natural and synthetic sources, whose
physicochemical properties, reactivity, and biological activities are well-known among the …

A class of quinazolone thiazoles was identified as new structural scaffolds for potential
antibacterial conquerors to tackle dreadful resistance. Some prepared compounds exhibited …

Due to the multifaceted pharmacological activities of chalcones, these scaffolds have been
considered one of the most privileged frameworks in the drug discovery process …

Alzheimer's disease (AD) is a multifactorial disorder strongly involving the formation of
amyloid-β (Aβ) oligomers, which subsequently aggregate into the disease characteristic …

The synthesis of the new hybrids followed a hybridization with the aid of hydroxy-
benzotriazole (HOBT) and 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDCI. HCL) in …

In this work, a series of chalcones (1a–d, 2a–d, 3a–d, 4a–d, and 5a–d) were designed and
synthesized by Claisen–Schmidt condensation. Also, their chemical structures were …

Despite the constant progress in the understanding of the etiopathogenesis of Alzheimer's
disease (AD) over the last 50 years, just four long-standing drugs are currently used for AD …

Originating from the basic chalcone structure, bis-chalcones are characterized by their dual
α, β-unsaturated carbonyl systems and carry a range of biological activities that include …

Searching for thiosemicarbazone derivatives with the potential to inhibit
acetylcholinesterase for the treatment of Alzheimer's disease (AD) is an important current …

Enones are widely utilized linchpin functional groups in chemical synthesis and molecular
biology. We herein report the direct conversion of boronic esters into enones using …