Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

The practice and theoretical basis of pain measurement is reviewed and critically examined
in the areas of animal research, human subjects laboratory investigation and clinical study …

A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive
ligatures around the common sciatic nerve. The postoperative behavior of these rats …

Partial nerve injury is the main cause of causalgiform pain disorders in humans. We present
here a novel animal model of this condition. In rats we unilaterally ligated about half of the …

Phantom pain refers to pain in a body part that has been amputated or deafferented. It has
often been viewed as a type of mental disorder or has been assumed to stem from …

Phantom-limb pain is a common sequela of amputation, occurring in up to 80% of people
who undergo the procedure. It must be differentiated from non-painful phantom phenomena …

In a prospective study 58 patients undergoing limb amputation were interviewed the day
before operation about their pre-amputation limb pain and 8 days, 6 months and 2 years …

Nonsynaptic interactions between neurons have been eclipsed by our increasingly detailed
understanding of chemical synapses, but they do play significant roles in the nervous …

We performed sensory assessments before and during diagnostic tourniquet-cuff and local
anesthetic blocks in 4 patients diagnosed with reflex sympathetic dystrophy (RSD). All …

Norepinephrine is involved in intrinsic control of pain. Main sources of norepinephrine are
sympathetic nerves peripherally and noradrenergic brainstem nuclei A1–A7 centrally …