COVID‐19 and comorbidities: A role for dipeptidyl peptidase 4 (DPP4) in disease severity?

MF Bassendine, SH Bridge, GW McCaughan… - Journal of …, 2020 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic is caused by a novel
betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), similar …

Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV

AM Lambeir, C Durinx, S Scharpé… - Critical reviews in …, 2003 - Taylor & Francis
Dipeptidyl-peptidase IV/CD26 (DPP IV) is a cell-surface protease belonging to the
prolyloligopeptidase family. It selectively removes the N-terminal dipeptide from peptides …

The multifunctional or moonlighting protein CD26/DPPIV

E Boonacker, CJF Van Noorden - European journal of cell biology, 2003 - Elsevier
CD26/DPPIV can be considered a moonlighting protein because it is a multifunctional
protein that exerts its different functions depending on cell type and intra-or extracellular …

CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes

MD Gorrell, V Gysbers… - Scandinavian journal of …, 2001 - Wiley Online Library
CD26 has proved interesting in the fields of immunology, endocrinology, cancer biology and
nutrition owing to its ubiquitous and unusual enzyme activity. This dipeptidyl …

Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog

HB Rasmussen, S Branner, FC Wiberg… - Nature structural …, 2003 - nature.com
Abstract Dipeptidyl peptidase IV (DPP-IV/CD26) is a multifunctional type II transmembrane
serine peptidase. This enzyme contributes to the regulation of various physiological …

DPP4 in cardiometabolic disease: recent insights from the laboratory and clinical trials of DPP4 inhibition

J Zhong, A Maiseyeu, SN Davis… - Circulation …, 2015 - Am Heart Assoc
The discovery of incretin-based medications represents a major therapeutic advance in the
pharmacological management of type 2 diabetes mellitus (T2DM), as these agents avoid …

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

M Engel, T Hoffmann, L Wagner… - Proceedings of the …, 2003 - National Acad Sciences
The membrane-bound glycoprotein dipeptidyl peptidase IV (DP IV, CD26) is a unique
multifunctional protein, acting as receptor, binding and proteolytic molecule. We have …

Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders

MD Gorrell - Clinical Science, 2005 - portlandpress.com
DP (dipeptidyl peptidase) IV is the archetypal member of its six-member gene family. Four
members of this family, DPIV, FAP (fibroblast activation protein), DP8 and DP9, have a rare …

Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X‐Pro dipeptides

C Durinx, AM Lambeir, E Bosmans… - European Journal of …, 2000 - Wiley Online Library
Dipeptidyl peptidase IV (DPPIV, EC 3.4. 14.5) is a serine type protease with an important
modulatory activity on a number of chemokines, neuropeptides and peptide hormones. It is …

[HTML][HTML] Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV

R Thoma, B Löffler, M Stihle, W Huber, A Ruf, M Hennig - Structure, 2003 - cell.com
Inhibition of dipeptidyl peptidase IV (DPP-IV), the main glucagon-like peptide 1 (GLP1)-
degrading enzyme, has been proposed for the treatment of type II diabetes. We expressed …