Multicomponent reactions (MCRs) are powerful synthetic tools in which more than two
starting materials couple with each other to form multi-functionalized compounds in a one …

More than 60 years have passed since I. Ugi synthesized the first α-amidoamides in one
experimental step involving a combination of aldehydes, amines, carboxylic acids and …

Beyond esoteric interest, organocatalysis has now become one major pillar of asymmetric
catalysis. Here, we discuss how new activation modes are conquering challenging …

The well‐defined conformational properties of axially chiral compounds bring extraordinary
values to an assortment of bioactive molecules, advanced materials, organocatalysts as well …

Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first
examples were reported 18 years ago by Akiyama and Terada. Although they were …

Multicomponent reactions (MCRs) undoubtedly correspond to one of the synthetic strategies
that best fit the new demands of chemistry for presenting high atom economy and enabling …

Multicomponent reactions 9i. e., those that engage three or more starting materials to form a
product that contains significant fragments of all of them), have been widely employed in the …

Ugi reactions and related variations are proven to be atom and step-economic strategies for
construction of highly valuable peptide-like skeletons and nitrogenous heterocycles. The …

Chiral spirocyclic phosphoric acids (SPAs) are introduced in 2010 and have been versatile
catalysts capable of promoting a wide range of asymmetric organocatalytic reactions, such …

Ligand-mediated nickel-catalyzed asymmetric hydrogenation of alkynone imines has been
achieved. By using Ni (OAc) 2· 4H2O/(S, S)-Ph-BPE complex as a catalyst, the chemo-and …