As the incidence of diabetes continues to increase in the western world, the prevalence of
chronic wounds related to this condition continues to be a major focus of wound care …

Abstract The World Health Organisation has deemed several multi-drug resistant (MDR)
nosocomial bacterial pathogens to be of significant threat to human health. A stark increase …

Antimicrobial peptides (AMP) are promising alternatives to classical antibiotics, due to their
high specificity and potency at low concentrations, and low propensity to elicit pathogen …

Antimicrobial peptides (AMP) are powerful components of the innate immune system, as
they display wide activity spectrum and low tendency to induce pathogen resistance. Hence …

The structural modification of existing AMPs is an effective strategy to develop antimicrobial
agents with high-efficiency, low-cost and low-toxicity antimicrobial agents. Methods: Here …

Owing to the challenges faced by conventional therapeutics, novel peptide antibiotics
against multidrug-resistant (MDR) gram-negative bacteria need to be urgently developed …

Abstract MSI-78A (Pexiganan A) is one of the few antimicrobial peptides (AMPs) able to kill
Helicobacter pylori, a pathogenic bacterium that colonizes the gastric mucosa of half of the …

Background The antibiotic resistance and biofilm formation of pathogenic microbes
exacerbate the difficulties of anti-infection therapy in the clinic. The structural modification of …

Wound infection treatment with antimicrobial peptides (AMPs) is still not a reality, due to the
loss of activity in vivo. Unlike the conventional strategy of encapsulating AMPs on …

Multidrug-resistant bacteria are a growing global concern, and with increasingly prevalent
resistance to last line antibiotics such as colistin, it is imperative that alternative treatment …