Breast cancer progression involves multiple genetic events, which can activate dominant-
acting oncogenes and disrupt the function of specific tumor suppressor genes. This article …

Human epidermal growth factor receptor 2 (HER2) receptor tyrosine kinase is
overexpressed in 20–30% of breast cancers and is associated with poor prognosis and …

Cell-surface receptors frequently use scaffold proteins to recruit cytoplasmic targets, but the
rationale for this is uncertain. Activated receptor tyrosine kinases, for example, engage …

We have examined whether inhibition of phosphatidylinositol-3 kinase (PI3K) and its target,
the serine/threonine kinase Akt, play a role in the antitumor effect of the HER2 antibody …

Publisher Summary This chapter focuses on the role played by ErbB receptors in cancer
progression. Cancer patients, whose tumors have alterations in ErbB1 or ErbB2, tend to …

Metastatic spread of cancer cells is the main cause of death of breast cancer patients, and
elucidation of the molecular mechanisms underlying this process is a major focus in cancer …

Amplification of the ErbB2 locus, which encodes a receptor tyrosine kinase, is common in
aggressive breast tumors and correlates with poor prognosis. The mechanisms underlying …

ErbB (also termed HER) receptors are expressed in various tissues of epithelial,
mesenchymal and neuronal origin, in which they are involved in the control of diverse …

Breast cancer (BC) is the most common cancer among women worldwide. Dietary fatty
acids, especially n-3 polyunsaturated fatty acids (PUFA), are believed to play a role in …

The adapter protein Shc was initially identified as an SH2 containing proto-oncogene
involved in growth factor signaling. Since then a number of studies in multiple systems have …