Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Acute pancreatitis (AP) is an inflammatory disease that can progress to severe acute
pancreatitis (SAP), which increases the risk of death. AP is characterized by inappropriate …

Background & Aims Sustained activation of the cytosolic calcium concentration induces
injury to pancreatic acinar cells and necrosis. The calcium release–activated calcium …

Key points This work confirms previous reports that CM4620, a small molecule inhibitor of
Ca2+ entry via store operated Ca2+ entry (SOCE) channels formed by stromal interaction …

An international symposium entitled “Acute pancreatitis: progress and challenges” was held
on November 5, 2014 at the Hapuna Beach Hotel, Big Island, Hawaii, as part of the 45th …

Knowledge of the molecular mechanisms of acute pancreatitis is largely based on studies
using rodents. To assess similar mechanisms in humans, we performed ex vivo pancreatitis …

The recent findings illuminate a critical role of organelles regulating the autophagic,
endolysosomal, mitochondrial, and ER pathways in maintaining pancreatic acinar cell …

Abstract Cav1. 2 L-type calcium channels play key roles in long-term synaptic plasticity,
sensory transduction, muscle contraction, and hormone release. De novo mutations in the …

Key points Bradykinin may play a role in the autodigestive disease acute pancreatitis, but
little is known about its pancreatic actions. In this study, we have investigated bradykinin …

In the adult, vascular smooth muscle cells (VSMC) are normally physiologically quiescent,
arranged circumferentially in one or more layers within blood vessel walls. Remodelling of …