ECM microenvironment in vascular homeostasis: new targets for atherosclerosis

L Zhang, Q Feng, W Kong - Physiology, 2024 - journals.physiology.org
Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical
properties influence both the formation and stability of atherosclerotic plaques. This review …

Contribution of the arterial cells to atherosclerosis and plaque formation

T Naiya, I Meganathan, N Ness… - American Journal …, 2024 - journals.physiology.org
Atherosclerosis is commonly known as an inflammatory disease that is characterized by lipid
deposition in the arterial wall, causing gradual restriction or complete blockade of blood …

Plasma proteomics and lipidomics facilitate elucidation of the link between Alzheimer's disease development and vessel wall fragility

SM Tokuoka, F Hamano, A Kobayashi, S Adachi… - Scientific Reports, 2024 - nature.com
Abstract Proximity Extension Assay (PEA) and mass spectrometry (MS) methodologies were
utilized for the proteomic and lipidomic characterization of plasma specimens from patients …

Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm

E Bouwens, A Vanmaele, SE Hoeks… - Vascular …, 2023 - journals.sagepub.com
Background: Surveillance programs in abdominal aortic aneurysms (AAA) are mainly based
on imaging and leave room for improvement to timely identify patients at risk for AAA growth …

Implications of Sm22α-Cre expression in keratinocytes and unanticipated inflammatory skin lesion in a model of atherosclerosis

M Hu, S Hiroyasu, DJ Granville… - American Journal of …, 2022 - journals.physiology.org
Genetically modified mice are widely used to recapitulate human diseases. Atherosclerosis
can be induced in mice with low-density lipoprotein receptor (Ldlr)-deficiency and a high-fat …

Altered brain expression and cerebrospinal fluid levels of TIMP4 in cerebral amyloid angiopathy

L Jäkel, AM De Kort, A Stellingwerf… - Acta Neuropathologica …, 2024 - Springer
Cerebral amyloid angiopathy (CAA) is a highly prevalent and progressive pathology,
involving amyloid-β (Aβ) deposition in the cerebral blood vessel walls. CAA is associated …

Loss of TIMP3, but not TIMP4, exacerbates thoracic and abdominal aortic aneurysm

M Hu, I Meganathan, J Zhu, R MacArthur… - Journal of Molecular and …, 2023 - Elsevier
Aims Aorta exhibits regional heterogeneity (structural and functional), while different
etiologies for thoracic and abdominal aortic aneurysm (TAA, AAA) are recognized. Tissue …

[HTML][HTML] Targeted proteomics and metabolomics for biomarker discovery in abdominal aortic aneurysm and post-EVAR sac volume

A Vanmaele, E Bouwens, SE Hoeks, A Kindt… - Clinica Chimica …, 2024 - Elsevier
Background and aims Abdominal aortic aneurysm (AAA) patients undergo uniform
surveillance programs both leading up to, and following surgery. Circulating biomarkers …

Colorectal cancer chemotherapy drug bevacizumab may induce muscle atrophy through CDKN1A and TIMP4

Q Xu, J Li, Y Wu, W Zhou, Z Xu - Frontiers in Oncology, 2022 - frontiersin.org
The muscle in the organism has the function of regulating metabolism. Long-term muscle
inactivity or the occurrence of chronic inflammatory diseases are easy to induce muscle …

MicroRNA-361-5p acts as a biomarker for carotid artery stenosis and promotes vascular smooth muscle cell proliferation and migration

F Wang, Y An, H Hao - BMC Medical Genomics, 2023 - Springer
Background Vascular smooth muscle cells (VSMCs) dysfunction participates in carotid artery
stenosis (CAS). The study aimed to examine the expression pattern of miR-361-5p in CAS …