Neuropathic pain; what we know and what we should do about it
PA Smith - Frontiers in Pain Research, 2023 - frontiersin.org
Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …
An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice
JN Siemian, MA Arenivar, S Sarsfield, CB Borja… - Elife, 2021 - elifesciences.org
Understanding how neuronal circuits control nociceptive processing will advance the search
for novel analgesics. We use functional imaging to demonstrate that lateral hypothalamic …
for novel analgesics. We use functional imaging to demonstrate that lateral hypothalamic …
Opioid-like adverse effects of tianeptine in male rats and mice
TR Baird, HI Akbarali, WL Dewey, H Elder, M Kang… - …, 2022 - Springer
Rationale Tianeptine is a mu-opioid receptor (MOR) agonist with increasing reports of abuse
in human populations. Preclinical data regarding the abuse potential and other opioid-like …
in human populations. Preclinical data regarding the abuse potential and other opioid-like …
Role of mu opioid receptor (MOR) agonist efficacy as a determinant of opioid antinociception in a novel assay of pain-depressed behavior in female and male mice
SS Negus, HI Akbarali, M Kang, YK Lee… - Frontiers in Pain …, 2023 - frontiersin.org
Introduction Intermediate efficacy mu opioid receptor (MOR) agonists have potential to retain
analgesic effectiveness while improving safety, but the optimal MOR efficacy for effective …
analgesic effectiveness while improving safety, but the optimal MOR efficacy for effective …
Effects of ketoprofen and morphine on pain-related depression of nestlet shredding in male and female mice
JB Garner, LS Marshall, NM Boyer, V Alapatt… - Frontiers in Pain …, 2021 - frontiersin.org
A primary goal in pain treatment is restoration of behaviors that are disrupted by pain.
Measures of pain interference indicate the degree to which pain interferes with activities in …
Measures of pain interference indicate the degree to which pain interferes with activities in …
Climbing behavior by mice as an endpoint for preclinical assessment of drug effects in the absence and presence of pain
EJ Santos, AN Giddings, FA Kandil… - Frontiers in Pain …, 2023 - frontiersin.org
This study evaluated climbing in mice as a tool to assess the expression and treatment of
pain-related behavioral depression in male and female ICR mice. Mice were videotaped …
pain-related behavioral depression in male and female ICR mice. Mice were videotaped …
Effects of Repeated Treatment with the Monoacylglycerol Lipase Inhibitor MJN110 on Pain-Related Depression of Nesting and Cannabinoid 1 Receptor Function in …
CM Diester, H Balint, JC Gillespie, AH Lichtman… - The Journal of …, 2024 - Elsevier
ABSTRACT MJN110 inhibits the enzyme monoacylglycerol lipase (MAGL) to increase levels
of the endocannabinoid 2-arachidonoylglycerol, an endogenous high-efficacy agonist of …
of the endocannabinoid 2-arachidonoylglycerol, an endogenous high-efficacy agonist of …
Novel bivalent ligands carrying potential antinociceptive effects by targeting putative mu opioid receptor and chemokine receptor CXCR4 heterodimers
The functional interactions between opioid and chemokine receptors have been implicated
in the pathological process of chronic pain. Mounting studies have indicated the possibility …
in the pathological process of chronic pain. Mounting studies have indicated the possibility …
[PDF][PDF] Low-Efficacy Mu Opioid Agonists as Candidate Analgesics: Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice
EJ Santos, HI Akbarali, EW Bow… - … of Pharmacology and …, 2024 - researchgate.net
Low efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics
with improved safety relative to high-efficacy opioids. This study used a recently validated …
with improved safety relative to high-efficacy opioids. This study used a recently validated …
Morphine exacerbates experimental colitis-induced depression of nesting in mice
SM Cheatham, KH Muchhala, E Koseli… - Frontiers in Pain …, 2021 - frontiersin.org
Opioids and non-steroidal anti-inflammatory drugs (NSAIDs) are excellent analgesics, but
recent clinical evidence suggests that these drugs might worsen disease severity in Crohn's …
recent clinical evidence suggests that these drugs might worsen disease severity in Crohn's …