Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …

Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review …

Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or
lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key …

The endosomal sorting complexes required for transport (ESCRT) drive multivesicular body
(MVB) biogenesis and cytokinetic abscission. Originally identified through genetics and cell …

Selective trafficking of membrane proteins to lysosomes for destruction is required for proper
cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins …

The endosomal sorting complexes required for transport (ESCRTs) catalyse one of the most
unusual membrane remodelling events in cell biology. ESCRT-I and ESCRT-II direct …

Many different globular domains bind to the surfaces of cellular membranes, or to specific
phospholipid components in these membranes, and this binding is often tightly regulated …

Most functions of eukaryotic cells are controlled by cellular membranes, which are not static
entities but undergo frequent budding, fission, fusion, and sculpting reactions collectively …

Primary cilium dysfunction underlies the pathogenesis of Bardet-Biedl syndrome (BBS), a
genetic disorder whose symptoms include obesity, retinal degeneration, and nephropathy …