Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …

Adenomatous polyposis coli (APC) is widely accepted as a tumor suppressor gene highly
mutated in colorectal cancers (CRC). Mutation and inactivation of this gene is a key and …

The acquisition of biallelic mutations in the APC gene is a rate-limiting step in the
development of most colorectal cancers and occurs in the earliest lesions. APC encodes a …

The intrinsic role of endogenous IL-17A in spontaneous intestinal tumorigenesis has not
been addressed previously to our knowledge. Ablation of IL-17A significantly reduced tumor …

Colorectal cancer is the third most common cancer worldwide. Although the transcription
factor c-MYC is misregulated in the majority of colorectal tumors, it is difficult to target …

Wnt proteins are a large family of secreted glycoproteins. Wnt proteins bind to the Frizzled
receptors and LRP5/6 co-receptors, and through stabilizing the critical mediator β-catenin …

Simple Summary Gene fusions produce chimeric fusion proteins with unpredictable
properties, many of which function as oncogenic drivers. ETV6-NTRK3 produces a …

Background Telomere shortening, dysfunction, and fusion may facilitate the acquisition of
large-scale genomic rearrangements, driving clonal evolution and tumor progression. The …

Colorectal cancer (CRC) is the second most lethal and the third most diagnosed type of
cancer worldwide. More than 75% of CRC cases are sporadic and lifestyle-related. Risk …

As oral squamous cell carcinoma (OSCC) can develop from potentially malignant disorders
(PMDs), it is critical to develop methods for early detection to improve the prognosis of …