Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities
RG Pertwee - … Transactions of the Royal Society B …, 2012 - royalsocietypublishing.org
Human tissues express cannabinoid CB1 and CB2 receptors that can be activated by
endogenously released 'endocannabinoids' or exogenously administered compounds in a …
endogenously released 'endocannabinoids' or exogenously administered compounds in a …
Cannabinoids and pain: sites and mechanisms of action
K Starowicz, DP Finn - Advances in Pharmacology, 2017 - Elsevier
The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …
Antidepressant‐like effects of fenofibrate in mice via the hippocampal brain‐derived neurotrophic factor signalling pathway
B Jiang, YJ Wang, H Wang, L Song… - British Journal of …, 2017 - Wiley Online Library
Background and Purpose Depression is a neuropsychiatric disorder accompanied by a
decrease in the brain‐derived neurotrophic factor (BDNF) signalling cascade in the …
decrease in the brain‐derived neurotrophic factor (BDNF) signalling cascade in the …
Application of the neuropeptide NPVF to enhance angiogenesis and osteogenesis in bone regeneration
H Yu, Y Wang, J Gao, Y Gao, C Zhong… - Communications …, 2023 - nature.com
The brain-bone regulatory system regulates skeletal homeostasis via bioactive
neuropeptides, yet the underlying mechanism remains elusive. Here, we report the role of …
neuropeptides, yet the underlying mechanism remains elusive. Here, we report the role of …
The role of the brain's endocannabinoid system in pain and its modulation by stress
Stress has a complex, bidirectional modulatory influence on pain. Stress may either reduce
(stress-induced analgesia) or exacerbate (stress-induced hyperalgesia) pain depending on …
(stress-induced analgesia) or exacerbate (stress-induced hyperalgesia) pain depending on …
BN‐9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance‐forming antinociception in mice
Background and Purpose Neuropeptide FF (NPFF) behaves as an endogenous opioid‐
modulating peptide. In the present study, the opioid and NPFF pharmacophore‐containing …
modulating peptide. In the present study, the opioid and NPFF pharmacophore‐containing …
Intrathecal injection of JWH015 attenuates remifentanil-induced postoperative hyperalgesia by inhibiting activation of spinal glia in a rat model
Y Sun, W Zhang, Y Liu, X Liu, Z Ma… - Anesthesia & Analgesia, 2014 - journals.lww.com
BACKGROUND: Hyperalgesia and neuroinflammation are associated with glia, which
consists of macroglia and microglia. In this study, we used a selective cannabinoid receptor …
consists of macroglia and microglia. In this study, we used a selective cannabinoid receptor …
Antinociceptive effects of central administration of the endogenous cannabinoid receptor type 1 agonist VDPVNFKLLSH-OH [(m) VD-hemopressin (α)], an N-terminally …
The cannabinoid system has been demonstrated to modulate the acute and chronic pain of
multiple origins. Mouse VD-hemopressin (α)[(m) VD-Hp α], an 11-residue α-hemoglobin …
multiple origins. Mouse VD-hemopressin (α)[(m) VD-Hp α], an 11-residue α-hemoglobin …
Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited …
Mounting evidences indicate the functional interactions between neuropeptide FF (NPFF)
and opioids, including the endogenous opioids. In the present work, EN-9, a chimeric …
and opioids, including the endogenous opioids. In the present work, EN-9, a chimeric …
The anti-inflammatory potential of neuropeptide FF in vitro and in vivo
YL Sun, XY Zhang, T Sun, N He, JY Li, Y Zhuang… - Peptides, 2013 - Elsevier
Neuropeptide FF (NPFF) has many functions in regulating various biological processes.
However, little attention has been focused on the anti-inflammatory effect of this peptide. In …
However, little attention has been focused on the anti-inflammatory effect of this peptide. In …