Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …

Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …

Addiction treatment has not been appreciably improved by neuroscientific research. One
problem is that mechanistic studies using rodent models do not incorporate volitional social …

Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …

Social reinforcement-based treatments are effective for many, but not all, people with
addictions to drugs. We recently developed an operant rat model that mimics features of one …

It was suggested in 1986 that cue-induced cocaine craving increases progressively during
early abstinence and remains high during extended periods of time. Clinical evidence now …

It is difficult to translate results from animal research on addiction to an understanding of the
behavior of human drug users. Despite decades of basic research on neurobiological …

Background We recently reported that operant social choice–induced voluntary abstinence
prevents incubation of methamphetamine craving. Here, we determined whether social …

Somatic cell nuclear transfer (SCNT) successfully clones cynomolgus monkeys, but the
efficiency remains low due to a limited understanding of the reprogramming mechanism …

Rationale Although increasingly subject to criticism, the brain disease model of addiction
(BDMA) remains dominant within addiction science. Yet few advocates or critics of the …