Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Neurons localize mRNAs near synapses where their translation can be regulated by
synaptic demand and activity. Differences in the 3′ UTRs of mRNAs can change their …

Our understanding of the molecular properties of kainate receptors and their involvement in
synaptic physiology has progressed significantly over the last 30 years. A plethora of studies …

Bipolar disorder is a mood disorder characterized by impairing episodes of mania and
depression. Twin studies have established that bipolar disorder is among the most heritable …

The advent of whole exome/genome sequencing and the technology-driven reduction in the
cost of next-generation sequencing as well as the introduction of diagnostic-targeted …

Schizophrenia (SZ) and bipolar disorder (BD) are debilitating neurobehavioural disorders
likely influenced by genetic and non-genetic factors and which can be seen as complex …

Schizophrenia and bipolar disorder are leading causes of morbidity across all populations,
with heritability estimates of∼ 80% indicating a substantial genetic component. Population …

Inherited ion channel mutations can affect the entire nervous system. Many cause
paroxysmal disturbances of brain, spinal cord, peripheral nerve or skeletal muscle function …

Synapses are complex structures that allow communication between neurons in the central
nervous system. Studies conducted in vertebrate and invertebrate models have contributed …