Is depression a global brain disorder with topographic dynamic reorganization?

G Northoff, D Hirjak - Translational Psychiatry, 2024 - nature.com
Major depressive disorder (MDD) is characterized by a multitude of psychopathological
symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal …

Psilocybin desynchronizes the human brain

JS Siegel, S Subramanian, D Perry, BP Kay… - Nature, 2024 - nature.com
A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …

Deep brain stimulation for refractory major depressive disorder: a comprehensive review

KA Johnson, MS Okun, KW Scangos, HS Mayberg… - Molecular …, 2024 - nature.com
Deep brain stimulation (DBS) has emerged as a promising treatment for select patients with
refractory major depressive disorder (MDD). The clinical effectiveness of DBS for MDD has …

Frontostriatal salience network expansion in individuals in depression

CJ Lynch, IG Elbau, T Ng, A Ayaz, S Zhu, D Wolk… - Nature, 2024 - nature.com
Decades of neuroimaging studies have shown modest differences in brain structure and
connectivity in depression, hindering mechanistic insights or the identification of risk factors …

Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial

CR Oehrn, S Cernera, LH Hammer, M Shcherbakova… - Nature Medicine, 2024 - nature.com
Deep brain stimulation (DBS) is a widely used therapy for Parkinson's disease (PD) but
lacks dynamic responsiveness to changing clinical and neural states. Feedback control …

Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder

NR Provenza, S Reddy, AK Allam, SV Rajesh, N Diab… - Nature Medicine, 2024 - nature.com
Recent advances in surgical neuromodulation have enabled chronic and continuous
intracranial monitoring during everyday life. We used this opportunity to identify neural …

Beta activity in human anterior cingulate cortex mediates reward biases

J Xiao, JA Adkinson, J Myers, AB Allawala… - Nature …, 2024 - nature.com
The rewards that we get from our choices and actions can have a major influence on our
future behavior. Understanding how reward biasing of behavior is implemented in the brain …

Automatic assessment method and device for depression symptom severity based on emotional facial expression and pupil-wave

M Li, Z Lu, Q Cao, J Gao, B Hu - IEEE Transactions on …, 2024 - ieeexplore.ieee.org
Depression is a serious mental disorder, significantly burdens individuals, families, and
society. For clinical psychiatrists, assessing the severity of depression is a crucial tool in …

Cortical beta oscillations map to shared brain networks modulated by dopamine

M Chikermane, L Weerdmeester, N Rajamani… - eLife, 2024 - elifesciences.org
Brain rhythms can facilitate neural communication for the maintenance of brain function.
Beta rhythms (13–35 Hz) have been proposed to serve multiple domains of human ability …

Subcallosal cingulate deep brain stimulation evokes two distinct cortical responses via differential white matter activation

A Seas, MS Noor, KS Choi… - Proceedings of the …, 2024 - National Acad Sciences
Subcallosal cingulate (SCC) deep brain stimulation (DBS) is an emerging therapy for
refractory depression. Good clinical outcomes are associated with the activation of white …