Abstract ATP-sensitive potassium (K ATP) channels are ubiquitously expressed on the
plasma membrane of cells in multiple organs, including the heart, pancreas and brain. K …

Background Worldwide, there is an increasing incidence of type 2 diabetes mellitus (T2DM).
Metformin is still the recommended first‐line glucose‐lowering drug for people with T2DM …

Older adults with chronic kidney disease (CKD) often experience polypharmacy, a
recognized predictor of prescribing problems including inappropriately dosed medications …

Heart failure with preserved ejection fraction (HFpEF) is a major unmet medical need that is
characterized by the presence of multiple cardiovascular and non-cardiovascular …

Metformin is a widely used anti-diabetic drug and increasing evidence suggests that
metformin have profound cardioprotective effects under both diabetic and non-diabetic …

Background While metformin has shown promise in treating septic myocardial injury (SMI),
its underlying mechanisms and impact on metabolic disturbances remain poorly understood …

Objectives: Identify the mechanism of action of glipizide. Describe the adverse effects of
glipizide. Summarize the appropriate monitoring of glipizide. Explain the importance of …

Influence of rosiglitazone on the myocardial apoptosis in rats with acute myocardial
infarction (AMI) via the Toll‑like receptor 4 (TLR4)/nuclear factor‑κB (NF‑κB) signaling …

Type 2 diabetes mellitus, sometimes referred to as non-insulin-dependent
diabetes,(NIDDM). The patient was unable to secrete enough insulin, resulting in elevated …

Introduction: Cardiovascular safety has become a central component of contemporary drug
development and therapeutic use since noncardiovascular drugs can exert cardiovascular …