Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

Citrullination of proteins, a post-translational conversion of arginine residues to citrulline, is
recognized in rheumatoid arthritis, but largely undocumented in cancer. Here we show that …

The role of the host extracellular matrix (ECM) in infection tends to be neglected. However,
the complex interactions between invading pathogens, host tissues and immune cells occur …

Increased attention is paid to the structural components of tissues. These components are
mostly collagens and various proteoglycans. Emerging evidence suggests that altered …

Glycosaminoglycans (GAGs) and proteoglycans (PGs) are essential components of the
extracellular matrix (ECM) with pivotal roles in cellular mechanosensing pathways. GAGs …

The biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial
in the processes of cell differentiation and proliferation. However, it is unclear to what extent …

The extracellular matrix (ECM) is present in all solid tissues and considered a master
regulator of cell behaviour and phenotype. The importance of maintaining the correct …

During cancer progression, the homeostasis of the extracellular matrix becomes imbalanced
with an excessive collagen remodeling by matrix metalloproteinases. As a consequence …

Biophysical cues stemming from the extracellular environment are rapidly transduced into
discernible chemical messages (mechanotransduction) that direct cellular activities–placing …

Abstract Effects of M2 tumour-associated macrophages on the pathogenesis of diffuse large
B cell lymphoma (DLBCL) are still controversial. Our data showed that the number of CD163 …