Despite the continuous advancement in neurosciences as well as in the knowledge of
human behaviors pathophysiology, currently suicide represents a puzzling challenge. The …

Abstract Treatment‑resistant depression (TRD) is a challenge for psychiatrists, even after
more than seven decades since the first antidepressants were used in clinical practice. Non …

A growing number of epidemiological and experimental studies has established that
circadian disruption is strongly associated with psychiatric disorders, including major …

The basal ganglia (BG) are a collection of interconnected subcortical nuclei that participate
in a great variety of functions, ranging from motor programming and execution to procedural …

Recent studies suggest a primary role of oxidative stress in an early phase of the
pathogenesis of schizophrenia and a strong neurobiological link has been found between …

The brain of Drosophila melanogaster is comprised of some 100,000 neurons, 127 and 80
of which are dopaminergic and serotonergic, respectively. Their activity regulates behavioral …

Almost all stroke survivors suffer physical disabilities and neuropsychiatric disturbances,
which can be briefly divided into post-stroke neurological diseases and post-stroke …

MicroRNAs (miRNAs) are a class of endogenous and non-coding single-stranded RNAs
with length of about 22 nucleotides, and many are evolutionarily conserved. Although …

α2A-and α2C-adrenoceptors (ARs) are the primary α2-AR subtypes involved in central
nervous system (CNS) function. These receptors are implicated in the pathophysiology of …

There is substantial evidence that cholinergic system function impairment plays a significant
role in many central nervous system (CNS) disorders. During the past three decades …