BTK inhibitors in the treatment of hematological malignancies and inflammatory diseases: mechanisms and clinical studies
A Alu, H Lei, X Han, Y Wei, X Wei - Journal of Hematology & Oncology, 2022 - Springer
Bruton's tyrosine kinase (BTK) is an essential component of multiple signaling pathways that
regulate B cell and myeloid cell proliferation, survival, and functions, making it a promising …
regulate B cell and myeloid cell proliferation, survival, and functions, making it a promising …
Role of Bruton's tyrosine kinase in B cells and malignancies
S Pal Singh, F Dammeijer, RW Hendriks - Molecular cancer, 2018 - Springer
Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …
signaling that is critical for proliferation and survival of leukemic cells in many B cell …
[HTML][HTML] Ibrutinib regimens versus chemoimmunotherapy in older patients with untreated CLL
JA Woyach, AS Ruppert, NA Heerema… - … England Journal of …, 2018 - Mass Medical Soc
Background Ibrutinib has been approved by the Food and Drug Administration for the
treatment of patients with untreated chronic lymphocytic leukemia (CLL) since 2016 but has …
treatment of patients with untreated chronic lymphocytic leukemia (CLL) since 2016 but has …
Targeting B cell receptor signalling in cancer: preclinical and clinical advances
JA Burger, A Wiestner - Nature Reviews Cancer, 2018 - nature.com
B cell receptor (BCR) signalling is crucial for normal B cell development and adaptive
immunity. BCR signalling also supports the survival and growth of malignant B cells in …
immunity. BCR signalling also supports the survival and growth of malignant B cells in …
Randomized trial of ibrutinib vs ibrutinib plus rituximab in patients with chronic lymphocytic leukemia
Ibrutinib, an oral covalent inhibitor of Bruton's tyrosine kinase, is an effective therapy for
patients with chronic lymphocytic leukemia (CLL). To determine whether rituximab provides …
patients with chronic lymphocytic leukemia (CLL). To determine whether rituximab provides …
Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia
Background Chronic lymphocytic leukemia (CLL) primarily affects older persons who often
have coexisting conditions in addition to disease-related immunosuppression and …
have coexisting conditions in addition to disease-related immunosuppression and …
Bruton tyrosine kinase–dependent immune cell cross-talk drives pancreas cancer
AJ Gunderson, MM Kaneda, T Tsujikawa, AV Nguyen… - Cancer discovery, 2016 - AACR
Pancreas ductal adenocarcinoma (PDAC) has one of the worst 5-year survival rates of all
solid tumors, and thus new treatment strategies are urgently needed. Here, we report that …
solid tumors, and thus new treatment strategies are urgently needed. Here, we report that …
Treatment of chronic lymphocytic leukemia
JA Burger - New England Journal of Medicine, 2020 - Mass Medical Soc
Chronic Lymphocytic Leukemia Treatment of CLL, the most common leukemia in the West,
has undergone a revolution in the past few years with the development of agents that target …
has undergone a revolution in the past few years with the development of agents that target …
Bruton's tyrosine kinase (BTK) inhibitors and autoimmune diseases: making sense of BTK inhibitor specificity profiles and recent clinical trial successes and failures
GE Ringheim, M Wampole, K Oberoi - Frontiers in immunology, 2021 - frontiersin.org
Clinical development of BTK kinase inhibitors for treating autoimmune diseases has lagged
behind development of these drugs for treating cancers, due in part from concerns over the …
behind development of these drugs for treating cancers, due in part from concerns over the …
Targeting Bruton's tyrosine kinase in B cell malignancies
RW Hendriks, S Yuvaraj, LP Kil - Nature Reviews Cancer, 2014 - nature.com
Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …
functions as an important regulator of cell proliferation and cell survival in various B cell …