Alkaloids and isoprenoids modification by copper (I)-catalyzed Huisgen 1, 3-dipolar cycloaddition (click chemistry): toward new functions and molecular architectures

K Kacprzak, I Skiera, M Piasecka, Z Paryzek - Chemical reviews, 2016 - ACS Publications
Despite enormous progress in the field of the synthetic chemistry involving, for example,
catalytic and combinatorial synthesis of a large libraries of compounds, multicomponent …

New click-chemistry methods for 1, 2, 3-triazoles synthesis: Recent advances and applications

J Totobenazara, AJ Burke - Tetrahedron letters, 2015 - Elsevier
Triazoles find applications in several major technological areas, and especially in drug
discovery. The click-chemistry approaches based on Huisgen's cycloaddition reaction are …

A review: Synthetic approaches and biological applications of triazole derivatives

U Salma, S Ahmad, MZ Alam, SA Khan - Journal of Molecular Structure, 2024 - Elsevier
The triazole scaffold is a key element in heterocyclic chemistry, giving a fundamental
building block in organic, medicinal chemistry, and material science. Triazole composed of a …

Design, synthesis, and antimicrobial activities of 1, 2, 3-triazole glycoside clickamers

T El Malah, HF Nour, AAE Satti, BA Hemdan… - Molecules, 2020 - mdpi.com
Bacterial resistance remains a significant threat and a leading cause of death worldwide,
despite massive attempts to control infections. In an effort to develop biologically active …

Therapeutic modulation of virus‐induced oxidative stress via the Nrf2‐dependent antioxidative pathway

C Lee - Oxidative Medicine and Cellular Longevity, 2018 - Wiley Online Library
Virus‐induced oxidative stress plays a critical role in the viral life cycle as well as the
pathogenesis of viral diseases. In response to reactive oxygen species (ROS) generation by …

Application of triazoles in the structural modification of natural products

HY Guo, ZA Chen, QK Shen… - Journal of enzyme …, 2021 - Taylor & Francis
Nature products have been extensively used in the discovery and development of new
drugs, as the most important source of drugs. The triazole ring is one of main …

Mono-and sesquiterpenes as a starting platform for the development of antiviral drugs

OI Yarovaya, NF Salakhutdinov - Russian Chemical Reviews, 2021 - iopscience.iop.org
The revies focuses on low-molecular-weight plant metabolites (mono-and sesquiterpenes)
exhibiting antiviral activity. Data on antiviral action of both essential oils and plant extracts …

Development of anti‐influenza agents from natural products

ZJ Zhang, SL Morris‐Natschke… - Medicinal research …, 2020 - Wiley Online Library
The influenza pandemic continues to threaten public health due to its high morbidity and
mortality rates, despite some successes in antiviral research. Natural drugs are important …

Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors

NH Zaher, MI Mostafa, AY Altaher - Acta Pharmaceutica, 2020 - hrcak.srce.hr
Sažetak Middle East respiratory syndrome coronavirus (MERS-CoV) had emerged and
spread because of the worldwide travel and inefficient healthcare provided for the infected …

Click chemistry-aided drug discovery: A retrospective and prospective outlook

R Zhao, J Zhu, X Jiang, R Bai - European Journal of Medicinal Chemistry, 2024 - Elsevier
Click chemistry has emerged as a valuable tool for rapid compound synthesis, presenting
notable advantages and convenience in the exploration of potential drug candidates. In …