An expanded analysis of pharmacogenetics determinants of efavirenz response that includes 3′-UTR single nucleotide polymorphisms among Black South African …
Introduction: Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor prescribed
as part of first-line highly active antiretroviral therapy (HAART) in South Africa. Despite …
as part of first-line highly active antiretroviral therapy (HAART) in South Africa. Despite …
Case report: Severe central nervous system manifestations associated with aberrant efavirenz metabolism in children: the role of CYP2B6 genetic variation
F Pinillos, C Dandara, M Swart, R Strehlau… - BMC infectious …, 2015 - Springer
Background Efavirenz, widely used as part of antiretroviral drug regimens in the treatment of
paediatric human immunodeficiency virus infection, has central nervous system side effects …
paediatric human immunodeficiency virus infection, has central nervous system side effects …
Effect of mid-dose efavirenz concentrations and CYP2B6 genotype on viral suppression in patients on first-line antiretroviral therapy
The therapeutic range for efavirenz plasma concentrations is unclear and some studies
found no correlation with viral non-suppression. Efavirenz concentrations are variable …
found no correlation with viral non-suppression. Efavirenz concentrations are variable …
Dose optimization of efavirenz based on individual CYP2B6 polymorphisms in Chinese patients positive for HIV
KH Hui, SS Lee, TN Lam - CPT: pharmacometrics & systems …, 2016 - Wiley Online Library
The purpose of this study was to investigate the impact of CYP2B6‐G516T polymorphisms
on the pharmacokinetics (PKs) of efavirenz among the Chinese population and to propose …
on the pharmacokinetics (PKs) of efavirenz among the Chinese population and to propose …
Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals
C de Almeida Velozo, TB de Almeida… - The …, 2022 - nature.com
Virologic failure of antiretroviral therapy (ART) may be explained by single nucleotide
polymorphisms (SNPs) in drug absorption and metabolism genes. Here, we characterized …
polymorphisms (SNPs) in drug absorption and metabolism genes. Here, we characterized …
Neuropsychiatric manifestations among HIV-1 infected African patients receiving efavirenz-based cART with or without tuberculosis treatment containing rifampicin
S Mugusi, E Ngaimisi, M Janabi, F Mugusi… - European Journal of …, 2018 - Springer
Purpose Efavirenz-based combination antiretroviral therapy (cART) is associated with
neuropsychiatric adverse events. We investigated the time to onset, duration, clinical …
neuropsychiatric adverse events. We investigated the time to onset, duration, clinical …
Meta-analysis of the associations of CYP2B6-516G> T polymorphisms with efavirenz-induced central nervous system side effects and virological outcome in HIV …
L Cheng, Y Wang, X Li, W Feng, B Weng… - The …, 2020 - nature.com
Clinical data on the relationships of cytochrome P450 (CYP2) B6 516G> T polymorphisms
with efavirenz-induced central nervous system (CNS) side effects and virological response …
with efavirenz-induced central nervous system (CNS) side effects and virological response …
[PDF][PDF] Sleep quality and immune changes in HIV positive people in the first six months of starting highly active antiretroviral therapy (HAART)
K Redman - Dr Diss, 2016 - wiredspace.wits.ac.za
ABSTRACT Introduction: South Africa has the highest absolute number of persons living
with HIV in the world. Previous research has shown that untreated and treated HIV positive …
with HIV in the world. Previous research has shown that untreated and treated HIV positive …
Estudio piloto de la evaluación calidad del sueño en pacientes VIH seguidos en las consultas de enfermedades infecciosas
B González López - dspace.umh.es
Introducción: Los pacientes VIH presentan peor calidad del sueño que la población general,
ligado a la afectación neuronal por la infección y al tratamiento antirretroviral entre otros …
ligado a la afectación neuronal por la infección y al tratamiento antirretroviral entre otros …
Using electronic methods of adherence monitoring and therapeutic drug monitoring (TDM) to eliminate discordance between antiretroviral adherence and virological …
C Orrell - 2016 - open.uct.ac.za
Background: Adherence to antiretroviral therapy (ART) is critical: only 70% achieve viral
suppression at a year. Current adherence methodologies, with slow reaction to missed …
suppression at a year. Current adherence methodologies, with slow reaction to missed …