Safety and efficacy data on many medicines used in children are surprisingly scarce. As a
result children are sometimes given ineffective medicines or medicines with unknown …

Objective To systematically review the evidence (and quality) for distraction and hypnosis for
needle-related pain and distress in children and adolescents. To explore the effects of …

Background This is the second update of a Cochrane Review (Issue 4, 2006). Pain and
distress from needle‐related procedures are common during childhood and can be reduced …

Objective To inform the design of a randomised controlled trial (called EcLiPSE) to improve
the treatment of children with convulsive status epilepticus (CSE). EcLiPSE requires the use …

Background Despite the critical importance of clinical trials to provide evidence about the
effects of intervention for children and youth, a paucity of published high-quality pediatric …

Ensuring parents make an informed decision about their child's participation in a clinical trial
is a challenge for practitioners as a parent's comprehension of a trial may differ from that …

Objective To identify practices that add value to improve the design, conduct, and reporting
of child health research and reduce research waste. Study design In order to categorize the …

Objective The Fluids in Shock (FiSh) Trial proposes to evaluate whether restrictive fluid
bolus therapy (10 mL/kg) is more beneficial than current recommended practice (20 mL/kg) …

Background In 2008 UK legislation was amended to enable the use of deferred consent for
paediatric emergency care (EC) trials in recognition of the practical and ethical difficulties of …

Background Procedural pain in children is highly prevalent, a major source of pain, stress
and anxiety, and can have negative short‐and long‐term effects. Research addressing …