Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of
gene control in humans. It provides cells with the opportunity to create protein isoforms of …

More than 95% of the 20,000 to 25,000 transcribed human genes undergo alternative RNA
splicing, which increases the diversity of the proteome. Isoforms derived from the same gene …

High-throughput technologies can now identify hundreds of candidate protein biomarkers for
any disease with relative ease. However, because there are no assays for the majority of …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor
prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the …

В обзоре описаны основные тенденции и направления персонализированной
медицины. Они включают предсказание на основе геномных данных вероятности …

Simple Summary Pancreatic ductal adenocarcinoma is a leading cause of cancer death
worldwide. Due to the frequently late diagnosis, early metastasis and high therapy …

Improvements in mass spectrometry (MS)-based peptide sequencing provide a new
opportunity to determine whether polymorphisms, mutations, and splice variants identified in …

The ability to sequence DNA rapidly, inexpensively and in a high‐throughput fashion
provides a unique opportunity to sequence whole genomes of a large number of species …

The search for tumor-specific antigens (TSAs) has considerably accelerated during the past
decade due to the improvement of proteogenomic detection methods. This provides new …

Biologically active proteins without stable tertiary structure are common in all known
proteomes. Functions of these intrinsically disordered proteins (IDPs) are typically related to …