Interspecific mouse backcrosses provide almost limitless genetic variation for gene
mapping. We have used interspecific backcrosses to develop the first comprehensive …

Plasmids comprising transgene insertions in four lines of transgenic mice have been
retrieved by plasmid rescue into a set of Escherichia coli strains with mutations in different …

Approximately 500 loci responsible for genetic disease in the mouse have been described
and mapped during the past 80 years-the so-called'classical mutations' of the mouse 1. As a …

The physiological roles of proteolysis are not limited to degrading unnecessary proteins.
Proteolysis plays pivotal roles in various biological processes through cleaving peptide …

The spontaneous autosomal recessive mouse mutation, Purkinje cell degeneration (pcd),
was first identified through its ataxic behavior. Since its discovery in the 1970s, the strain has …

Increasing numbers of transgenic mouse lines have resulted in several dozens of mutants
created by insertional mutagenesis. The advantages of different vector systems and the …

A line of transgenic mice that carries an insertional mutation in a gene essential for
spermatogenesis is described. Males homozygous for the transgenic insert are sterile, while …

Purkinje cell degeneration (pcd) was first identified in a spontaneous mouse mutant showing
cerebellar ataxia. In addition to cerebellar Purkinje cells (PC s), retinal photoreceptors, mitral …

In the wobbler (WR) mouse, a neuromuscular mutant characterized by a motoneuron
degeneration and male infertility, the cellular basis of the defect in spermiogenesis was …

Mutant mice have been collected for many years. At the start, this collection, referred to as
the mouse fancy, included mice selected on the basis of mor phological criteria, such as tail …