Oncogene activation and tumor-suppressor gene inactivation are considered as the main
causes driving the transformation of normal somatic cells into malignant tumor cells. Cancer …

What is the relationship between the wound-healing process and the development of
cancer? Malignant tumours often develop at sites of chronic injury, and tissue injury has an …

The earlier diagnosis of cancer is one of the keys to reducing cancer deaths in the future.
Here we describe our efforts to develop a noninvasive blood test for the detection of …

The Wnt/β-catenin pathway, which signals through the Frizzled (Fzd) receptor family and
several coreceptors, has long been implicated in cancer. Here we demonstrate a therapeutic …

Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN
is involved in normal physiological processes and is implicated in the pathogenesis of a …

Recent research has led to a better but as yet incomplete understanding of the complex
roles osteopontin plays in mammalian physiology. A soluble protein found in all body fluids …

Purpose The role of the microenvironment during the initiation and progression of
carcinogenesis is now realized to be of critical importance, both for enhanced understanding …

The diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it
into an attractive natural compound in different health‐related problems. A great body of …

The extracellular matrix is a structure composed of many molecules, including fibrillar (types
I, II, III, V, XI, XXIV, XXVII) and non-fibrillar collagens (mainly basement membrane collagens …

Numerous components and pathways are involved in the complex interplay between cancer
cells and their environment. The family of glycophosphoproteins comprising osteopontin …