Cortical dysfunction—specifically, the development of hyperexcitability—seems to be an
early and intrinsic feature of sporadic and familial amyotrophic lateral sclerosis (ALS) …

Amyotrophic lateral sclerosis (ALS) is the most common and most aggressive form of adult
motor neuron (MN) degeneration. The cause of the disease is still unknown, but some …

Protein and peptides are converted from their soluble forms into highly ordered fibrillar
aggregates under various conditions inside the cell. Such transitions confer diverse …

The excitatory neurotransmission of the central nervous system (CNS) mainly involves
glutamate and its receptors, especially N-methyl-D-Aspartate receptors (NMDARs). These …

Neurodegeneration describes a group of more than 300 neurological diseases,
characterised by neuronal loss and intra-or extracellular protein depositions, as key …

Glutamate is the major excitatory neurotransmitter in the brain, and it is widely accepted to
play a role in synaptic plasticity and excitotoxic cell death. Glutamate binds to several …

Cortical hyperexcitability is an early and intrinsic feature of both sporadic and familial forms
of amyotrophic lateral sclerosis (ALS).. Importantly, cortical hyperexcitability appears to be …

Amyotrophic lateral sclerosis (ALS) is characterized by a progressive degeneration of upper
and lower motor neurons, resulting in fatal paralysis due to denervation of the muscle. Due …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease and is
clinically characterised by the death of corticospinal motor neurons (CSMNs), spinal and …

Amyotrophic lateral sclerosis (ALS) is a lethal disorder characterized by the gradual
degeneration of motor neurons in the cerebrospinal axis. Whether upper motor neuron …