Cushing's syndrome

A Lacroix, RA Feelders, CA Stratakis, LK Nieman - The lancet, 2015 - thelancet.com
Chronic exposure to excess glucorticoids results in diverse manifestations of Cushing's
syndrome, including debilitating morbidities and increased mortality. Genetic and molecular …

Clinical, pathophysiologic, genetic, and therapeutic progress in primary bilateral macronodular adrenal hyperplasia

J Bertherat, I Bourdeau, L Bouys… - Endocrine …, 2023 - academic.oup.com
Patients with primary bilateral macronodular adrenal hyperplasia (PBMAH) usually present
bilateral benign adrenocortical macronodules at imaging and variable levels of cortisol …

Management of endocrine disease: differential diagnosis, investigation and therapy of bilateral adrenal incidentalomas

I Bourdeau, N El Ghorayeb, N Gagnon… - European journal of …, 2018 - academic.oup.com
The investigation and management of unilateral adrenal incidentalomas have been
extensively considered in the last decades. While bilateral adrenal incidentalomas represent …

Adrenocortical tumorigenesis: Lessons from genetics

CDC Kamilaris, F Hannah-Shmouni… - Best Practice & Research …, 2020 - Elsevier
Advances in genomics over the past two decades have allowed for elucidation of the genetic
alterations leading to the development of adrenocortical tumors and/or hyperplasias. These …

Update on primary bilateral macronodular adrenal hyperplasia (PBMAH)

L Bouys, I Chiodini, W Arlt, M Reincke, J Bertherat - Endocrine, 2021 - Springer
Primary bilateral macronodular adrenal hyperplasia (PBMAH), characterized by bilateral
benign adrenal macronodules (> 1 cm) potentially responsible for variable levels of cortisol …

Diagnosis and management of primary bilateral macronodular adrenal hyperplasia

DA Vassiliadi, S Tsagarakis - Endocrine-Related Cancer, 2019 - erc.bioscientifica.com
Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a highly heterogeneous
entity. The incidental identification of an increasing number of cases has shifted its clinical …

Disorders of the adrenal cortex: Genetic and molecular aspects

G Pitsava, AG Maria, FR Faucz - Frontiers in Endocrinology, 2022 - frontiersin.org
Adrenal cortex produces glucocorticoids, mineralocorticoids and adrenal androgens which
are essential for life, supporting balance, immune response and sexual maturation …

Genetics of tumors of the adrenal cortex

F Bonnet-Serrano, J Bertherat - Endocrine-related cancer, 2018 - erc.bioscientifica.com
This review describes the molecular alterations observed in the various types of tumors of
the adrenal cortex, excluding Conn adenomas, especially the alterations identified by …

Bilateral adrenal hyperplasia: pathogenesis and treatment

B Chevalier, MC Vantyghem, S Espiard - Biomedicines, 2021 - mdpi.com
Bilateral adrenal hyperplasia is a rare cause of Cushing's syndrome. Micronodular adrenal
hyperplasia, including the primary pigmented micronodular adrenal dysplasia (PPNAD) and …

An analysis of different therapeutic options in patients with C ushing's syndrome due to bilateral macronodular adrenal hyperplasia: a single‐centre experience

NM Albiger, F Ceccato, M Zilio, M Barbot… - Clinical …, 2015 - Wiley Online Library
Context Bilateral macronodular adrenal hyperplasia (BMAH) is a rare form of Cushing's
syndrome (CS). A variety of in vivo tests to identify aberrant receptor expression have been …