Epigenetic pathways play a pivotal role in the development and function of the immune
system. Over the last decade, a growing body of studies has been published out seeking to …

Systemic sclerosis (SSc) is a prototypical inflammatory fibrotic disease involving
inflammation, vascular abnormalities and fibrosis that primarily affect the skin and lungs. The …

Although the function of DNA methylation in gene promoter regions is well established in
transcriptional repression, the function of the evolutionarily conserved widespread …

Systemic sclerosis is a complex autoimmune disease characterized by a chronic and
frequently progressive course and by extensive patient-to-patient variability. Like other …

The current paradigm of onset and progression of periodontitis includes oral dysbiosis
directed by inflammophilic bacteria, leading to altered resolution of inflammation and lack of …

Systemic lupus erythematosus (SLE) is an autoimmune disease with manifestations derived
from the involvement of multiple organs including the kidneys, joints, nervous system and …

Objective To identify microRNA genes with abnormal expression in the CD4+ T cells of
patients with systemic lupus erythematosus (SLE) and to determine the role of microRNA …

One of the major disappointments in human autoimmunity has been the relative failure on
genome-wide association studies to provide “smoking genetic guns” that would explain the …

Introduction We assessed the profile and frequency of malignancy subtypes in a large single-
centre UK cohort for patients with scleroderma (systemic sclerosis; SSc). We evaluated the …

Advances in genetics, such as sequencing of the human genome, have contributed to
identification of susceptible genetic patterns in autoimmune diseases (AID). However …