More than a decade ago, the first genome-scale metabolic models for two of the most
relevant microbes for biotechnology applications, Escherichia coli and Saccaromyces …

Metabolic engineering requires multiple rounds of strain construction to evaluate alternative
pathways and enzyme concentrations. Optimizing multigene pathways stepwise or by …

The ethylene-forming enzyme (EFE) from Pseudomonas syringae pv. phaseolicola PK2 is a
member of the mononuclear non-heme Fe (II)-and 2-oxoglutarate (2OG)-dependent …

Metabolic engineers manipulate intricate biological networks to build efficient biological
machines. The inherent complexity of this task, derived from the extensive and often …

Economically-viable biofuel production is often limited by low levels of microbial tolerance to
high biofuel concentrations. Here we demonstrate the first application of deactivated …

Constraint‐based reconstruction and analysis (COBRA) is one of the most widely used
modeling approaches for describing and simulating cellular systems in silico. It has been …

There has been a steep rise in the number of genome‐scale metabolic models that are
available. These models have been a popular choice for designing cell factories given the …

The Escherichia coli metabolism was modeled at the genome scale for the first time more
than a decade ago. Since then, the E. coli genome‐scale models (GEMs) have been …

Correction: CONSTRICTOR: Constraint Modification Provides Insight into Design of
Biochemical Networks Page 1 Correction Correction: CONSTRICTOR: Constraint …

The capabilities of Escherichia coli and Zymomonas mobilis to efficiently converting
substrate into valuable metabolites have caught the attention of many industries. However …