Cancer is one of the most fatal diseases of recent times that causes several deaths every
year. The disease variations in different parts of the world, the impact of available medical …

Cyclic peptides extend the druggable target space due to their size, flexibility, and hydrogen-
bonding capacity. However, these properties impact also their passive membrane …

Cheese is the potential great source of umami peptides, while studies on umami peptides in
cheese are scant and current sensory-guided strategies are difficult for rapid and high …

Cyclic peptides have the potential to vastly extend the scope of druggable proteins and lead
to new therapeutics for currently untreatable diseases. However, cyclic peptides often suffer …

Motivation Cyclization is a common strategy to enhance the therapeutic potential of
peptides. Many cyclic peptide drugs have been approved for clinical use, in which the …

The biological significance of benzopyran-4-ones as cytotoxic agents against multi-drug
resistant cancer cell lines and isoxazoles as anti-inflammatory agents in cellular assays …

This study aimed to rapidly develop novel umami peptides using yeast protein as an
alternative protein source. Yeast protein hydrolysates exhibiting pronounced umami …

Macrocyclic peptides possess unique features, making them highly promising as a drug
modality. However, evaluating their bioactivity through wet lab experiments is generally …

Doxorubicin (Dox) is an anthracycline chemotherapeutic agent used to treat breast,
leukemia, and lymphoma malignancies. However, cardiotoxicity and inherent acquired …

Protein kinases become an important source of potential drug targets. Developing new,
efficient, and safe small-molecule kinase inhibitors has become an important topic in the …