Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …

The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-
inducing ligand), are critical factors in the maintenance of the B cell pool and humoral …

IgA nephropathy is the most common form of glomerulonephritis in many parts of the world
and remains an important cause of end-stage renal disease. Current evidence suggests that …

B cells are central to the pathogenesis of multiple autoimmune diseases, through antigen
presentation, cytokine secretion, and the production of autoantibodies. During development …

The therapeutic benefit of depleting B cells in rheumatoid arthritis (RA) has refocused
attention on B cells with increasing awareness on their role in autoimmunity and their …

BAFF (B lymphocyte activating factor of the tumour necrosis factor family) is a vital
homeostatic cytokine for B cells that helps regulate both innate and adaptive immune …

BACKGROUND: Chronic rhinosinusitis (CRS) with nasal polyps is an inflammatory condition
of the nasal passage and paranasal sinuses characterized by TH2-biased inflammation with …

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis.
Several observations suggest that gut microbiota could be implicated in IgAN …

Rationale: Patients with chronic obstructive pulmonary disease (COPD) have increased
pulmonary lymphoid follicle (LF) counts. B cell–activating factor of tumor necrosis factor …

Age is the most important risk factor for the development of infectious diseases, cancer and
chronic inflammatory diseases including rheumatoid arthritis (RA). The very act of living …