Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

[HTML][HTML] Invasive candidiasis

PG Pappas, MS Lionakis, MC Arendrup… - Nature Reviews …, 2018 - nature.com
Invasive candidiasis is an important health-care-associated fungal infection that can be
caused by several Candida spp.; the most common species is Candida albicans, but the …

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

L Galluzzi, JM Bravo-San Pedro, B Levine… - Nature reviews Drug …, 2017 - nature.com
Autophagy is central to the maintenance of organismal homeostasis in both physiological
and pathological situations. Accordingly, alterations in autophagy have been linked to …

p62/SQSTM 1:'Jack of all trades' in health and cancer

P Sánchez‐Martín, T Saito, M Komatsu - The FEBS journal, 2019 - Wiley Online Library
p62 is a stress‐inducible protein able to change among binding partners, cellular
localizations and form liquid droplet structures in a context‐dependent manner. This protein …

Aspergillus cell wall melanin blocks LC3-associated phagocytosis to promote pathogenicity

T Akoumianaki, I Kyrmizi, I Valsecchi, MS Gresnigt… - Cell host & …, 2016 - cell.com
Concealing pathogen-associated molecular patterns (PAMPs) is a principal strategy used by
fungi to avoid immune recognition. Surface exposure of PAMPs during germination can …

Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation

Z Wang, H Zhou, H Zheng, X Zhou, G Shen, X Teng… - Autophagy, 2021 - Taylor & Francis
The precise mechanism through which macroautophagy/autophagy affects psoriasis is
poorly understood. Here, we found that keratinocyte (KC) autophagy, which was positively …

Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation

TT Tang, LL Lv, MM Pan, Y Wen, B Wang, ZL Li… - Cell death & …, 2018 - nature.com
Inflammation is a major contributor to the pathogenesis of ischemic acute kidney injury (AKI),
which complicates the post-operative outcomes of large numbers of hospitalized surgical …

The therapeutic and pathogenic role of autophagy in autoimmune diseases

H Yin, H Wu, Y Chen, J Zhang, M Zheng… - Frontiers in …, 2018 - frontiersin.org
Autophagy is a complicated cellular mechanism that maintains cellular and tissue
homeostasis and integrity via degradation of senescent, defective subcellular organelles …

ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury

X Peng, Y Wang, H Li, J Fan, J Shen, X Yu… - Cell Death & …, 2019 - nature.com
G2/M-arrested proximal tubular epithelial cells (TECs) after renal injury are linked to
increased cytokines production. ATG5-mediated autophagy in proximal TECs has recently …

Splenic macrophage subsets and their function during blood-borne infections

H Borges da Silva, R Fonseca, RM Pereira… - Frontiers in …, 2015 - frontiersin.org
The spleen is one of the major immunological sites for maintaining blood homeostasis.
Previous studies showed that heterogeneous splenic macrophage populations contribute in …