Molecular mechanisms of viral oncogenesis in humans

NA Krump, J You - Nature Reviews Microbiology, 2018 - nature.com
Viral infection is a major contributor to the global cancer burden. Recent advances have
revealed that seven known oncogenic viruses promote tumorigenesis through shared host …

[HTML][HTML] Virology and cell biology of the hepatitis C virus life cycle–An update

J Dubuisson, FL Cosset - Journal of hepatology, 2014 - Elsevier
Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis
and hepatocellular carcinoma. It imposes a serious problem to public health in the world as …

The ins and outs of hepatitis C virus entry and assembly

BD Lindenbach, CM Rice - Nature Reviews Microbiology, 2013 - nature.com
Hepatitis C virus, a major human pathogen, produces infectious virus particles with several
unique features, such as an ability to interact with serum lipoproteins, a dizzyingly …

[HTML][HTML] A twist of FATe: Lipid droplets and inflammatory lipid mediators

E Jarc, T Petan - Biochimie, 2020 - Elsevier
Lipid droplets are fat storage organelles present in most eukaryotic cells. They consist of a
neutral lipid core containing mostly triglycerides and sterol esters and covered by a …

Hepatitis C virus RNA replication and assembly: living on the fat of the land

D Paul, V Madan, R Bartenschlager - Cell host & microbe, 2014 - cell.com
Hepatitis C virus (HCV) is a major global health burden accounting for around 170 million
chronic infections worldwide. Although highly potent direct-acting antiviral drugs to treat …

Picornavirus morphogenesis

P Jiang, Y Liu, HC Ma, AV Paul… - … and Molecular Biology …, 2014 - Am Soc Microbiol
The Picornaviridae represent a large family of small plus-strand RNA viruses that cause a
bewildering array of important human and animal diseases. Morphogenesis is the least …

The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses

A Schreiber, D Viemann, J Schöning, S Schloer… - Cellular and Molecular …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19), the illness caused by a novel coronavirus
now called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to more …

[HTML][HTML] Gut microbiota and host metabolism in liver cirrhosis

M Usami, M Miyoshi, H Yamashita - World journal of …, 2015 - ncbi.nlm.nih.gov
The gut microbiota has the capacity to produce a diverse range of compounds that play a
major role in regulating the activity of distal organs and the liver is strategically positioned …

Phospholipase A2 regulation of lipid droplet formation

C Guijas, JP Rodríguez, JM Rubio, MA Balboa… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The classical regard of lipid droplets as mere static energy-storage organelles has evolved
dramatically. Nowadays these organelles are known to participate in key processes of cell …

Inhibition of Cytosolic Phospholipase A2α Impairs an Early Step of Coronavirus Replication in Cell Culture

C Müller, M Hardt, D Schwudke, BW Neuman… - Journal of …, 2018 - Am Soc Microbiol
Coronavirus replication is associated with intracellular membrane rearrangements in
infected cells, resulting in the formation of double-membrane vesicles (DMVs) and other …