An update on diagnostic and prognostic biomarkers for traumatic brain injury

KK Wang, Z Yang, T Zhu, Y Shi… - Expert review of …, 2018 - Taylor & Francis
Introduction: Traumatic brain injury (TBI) is a major worldwide neurological disorder of
epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms …

A literature review of traumatic brain injury biomarkers

HS Ghaith, AA Nawar, MD Gabra… - Molecular …, 2022 - Springer
Research into TBI biomarkers has accelerated rapidly in the past decade owing to the
heterogeneous nature of TBI pathologies and management, which pose challenges to TBI …

A review of the clinical utility of serum S100B protein levels in the assessment of traumatic brain injury

EP Thelin, DW Nelson, BM Bellander - Acta neurochirurgica, 2017 - Springer
Background In order to improve injury assessment of brain injuries, protein markers of
pathophysiological processes and tissue fate have been introduced in the clinic. The most …

A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury

ME Shenton, HM Hamoda, JS Schneiderman… - Brain imaging and …, 2012 - Springer
Mild traumatic brain injury (mTBI), also referred to as concussion, remains a controversial
diagnosis because the brain often appears quite normal on conventional computed …

Military traumatic brain injury: a challenge straddling neurology and psychiatry

LZ Kong, RL Zhang, SH Hu, JB Lai - Military medical research, 2022 - Springer
Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible
effect of the war. In this review, we begin by examining related military research …

Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury …

L Papa, LM Lewis, S Silvestri, JL Falk… - Journal of Trauma …, 2012 - journals.lww.com
BACKGROUND: This study compared early serum levels of ubiquitin C-terminal hydrolase
(UCH-L1) from patients with mild and moderate traumatic brain injury (TBI) with uninjured …

Therapy development for diffuse axonal injury

DH Smith, R Hicks, JT Povlishock - Journal of neurotrauma, 2013 - liebertpub.com
Diffuse axonal injury (DAI) remains a prominent feature of human traumatic brain injury (TBI)
and a major player in its subsequent morbidity. The importance of this widespread axonal …

Human traumatic brain injury induces autoantibody response against glial fibrillary acidic protein and its breakdown products

Z Zhang, JS Zoltewicz, S Mondello, KJ Newsom… - PloS one, 2014 - journals.plos.org
The role of systemic autoimmunity in human traumatic brain injury (TBI) and other forms of
brain injuries is recognized but not well understood. In this study, a systematic investigation …

Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury

S Mondello, A Linnet, A Buki, S Robicsek… - …, 2012 - journals.lww.com
BACKGROUND: Brain damage markers released in cerebrospinal fluid (CSF) and blood
may provide valuable information about diagnosis and outcome prediction after traumatic …

Biokinetic analysis of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids

GM Brophy, S Mondello, L Papa, SA Robicsek… - Journal of …, 2011 - liebertpub.com
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a neuron-specific enzyme that has been
identified as a potential biomarker of traumatic brain injury (TBI). The study objectives were …