Purpose Harmful effects of ionizing radiation on the Central Nervous System (CNS) are a
concerning outcome in the field of cancer radiotherapy and form a major risk for deep space …

Background Alzheimer's disease (AD) is a neurodegenerative disorder and the predominant
type of dementia worldwide. It is characterized by the progressive and irreversible decline of …

Purpose Distinguishing radiation necrosis (RN) from recurrent tumor remains a vexing
clinical problem with important health-care consequences for neuro-oncology patients …

Background Radionecrosis is a common complication in radiation oncology, while
mechanisms and risk factors have yet to be fully explored. We therefore conducted a …

Modeling of metastatic disease in animal models is a critical resource to study the
complexity of this multi-step process in a relevant system. Available models of metastatic …

Although intravenous bevacizumab (IVBEV) is the most promising treatment for cerebral
radiation necrosis (CRN), there is no conclusion on the optimal dosage. Our retrospective …

Purpose Glioblastoma (GBM) remains incurable, despite state-of-the-art treatment involving
surgical resection, chemotherapy, and radiation. GBM invariably recurs as a highly invasive …

Purpose There is mounting evidence that, in addition to angiogenesis, hypoxia-induced
inflammation via the hypoxia-inducible factor 1α (HIF-1α)–CXC chemokine receptor 4 …

Background and purpose Radiation necrosis is a possible adverse event after cranial
radiation therapy and can cause severe symptoms, such as an increased intracranial …

Purpose Clinical evidence suggests radiation induces changes in the brain
microenvironment that affect subsequent response to treatment. This study investigates the …