In the past few decades, the development of heat shock protein 90 (Hsp90) inhibitors for
cancer treatment has not stopped. About twenty compounds have been evaluated in the …

Abnormal energy metabolism is a characteristic of tumor cells, and mitochondria are
important components of tumor metabolic reprogramming. Mitochondria have gradually …

Binding of the mitochondrial chaperone TRAP1 to client proteins shapes bioenergetic and
proteostatic adaptations of cells, but the panel of TRAP1 clients is only partially defined …

Mitochondrial function is dependent on molecular chaperones, primarily due to their
necessity in the formation of respiratory complexes and clearance of misfolded proteins …

Melanoma and its associated alterations in cellular pathways have been growing areas of
interest in research, especially as specific biological pathways are being elucidated. Some …

Currently there is great interest in targeting mitochondrial oxidative phosphorylation
(OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases …

TRAP1, the mitochondrial component of the Hsp90 family of molecular chaperones, displays
important bioenergetic and proteostatic functions. In tumor cells, TRAP1 contributes to shape …

Molecular chaperones have recently emerged as fundamental regulators of salient
biological routines, including metabolic adaptations to environmental changes. Yet, many of …

Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member of the heat shock
protein 90 (Hsp90) chaperone family, protects cells against oxidative stress and maintains …

TRAP1, the mitochondrial isoform of heat shock protein (Hsp) 90 chaperones, is a key
regulator of metabolism and organelle homeostasis in diverse pathological states. While …