Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits

KJ Ressler, S Berretta, VY Bolshakov… - Nature Reviews …, 2022 - nature.com
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …

[HTML][HTML] The role of the immune system in posttraumatic stress disorder

S Katrinli, NCS Oliveira, JC Felger… - Translational …, 2022 - nature.com
Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to
traumatic stress. In addition to well-defined psychological and behavioral symptoms, some …

Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores

O Weissbrod, M Kanai, H Shi, S Gazal, WJ Peyrot… - Nature Genetics, 2022 - nature.com
Polygenic risk scores suffer reduced accuracy in non-European populations, exacerbating
health disparities. We propose PolyPred, a method that improves cross-population …

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

N Mullins, AJ Forstner, KS O'Connell, B Coombes… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

[HTML][HTML] Gut microbiota and psychiatric disorders: a two-sample Mendelian randomization study

JJ Ni, Q Xu, SS Yan, BX Han, H Zhang, XT Wei… - Frontiers in …, 2022 - frontiersin.org
Evidence supports the observational associations of gut microbiota with a variety of
psychiatric disorders, but the causal nature of such associations remains obscure. Aiming to …

Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program

MB Stein, DF Levey, Z Cheng, FR Wendt… - Nature …, 2021 - nature.com
We conducted genome-wide association analyses of over 250,000 participants of European
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …

Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis

AD Grotzinger, TT Mallard, WA Akingbuwa, HF Ip… - Nature …, 2022 - nature.com
We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …

Transcriptomic organization of the human brain in post-traumatic stress disorder

MJ Girgenti, J Wang, D Ji, DA Cruz, MB Stein… - Nature …, 2021 - nature.com
Despite extensive study of the neurobiological correlates of post-traumatic stress disorder
(PTSD), little is known about its molecular determinants. Here, differential gene expression …

Genetics of substance use disorders in the era of big data

J Gelernter, R Polimanti - Nature Reviews Genetics, 2021 - nature.com
Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …

[PDF][PDF] Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain

MN Tran, KR Maynard, A Spangler, LA Huuki… - Neuron, 2021 - cell.com
Single-cell gene expression technologies are powerful tools to study cell types in the human
brain, but efforts have largely focused on cortical brain regions. We therefore created a …