Introduction: Traumatic brain injury (TBI) is a major worldwide neurological disorder of
epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms …

Genotyping tumor tissue in search of somatic genetic alterations for actionable information
has become routine practice in clinical oncology. Although these sequence alterations are …

Endogenous DNA is primarily found intracellularly in nuclei and mitochondria. However,
extracellular, cell-free (cf) DNA, has been observed in several pathological conditions …

This article reviews recent developments in the application of cell-free DNA-based liquid
biopsies to neurological diseases. Over the past few decades, an explosion of interest in the …

Background Neutrophils release neutrophil extracellular traps (NETs) in response to
invading pathogens. Although NETs play an important role in host defense against microbial …

Body fluids are constantly replenished with a population of genetically diverse cell-free DNA
(cfDNA) fragments, representing a vast reservoir of information reflecting real-time changes …

Since the discovery of cell-free DNA (cfDNA) in human blood, most studies have focused on
diagnostic and prognostic uses of these markers for solid tumors. Except for some prenatal …

Introduction The aims of this study were to assess the reliability of circulating cell-free DNA
(cf-DNA) concentrations, compared with C-reactive protein (CRP), procalcitonin (PCT) and …

Cell-free DNA (cfDNA) in body tissues or fluids is extensively investigated in clinical
medicine and other research fields. In this article we provide a direct quantitative real-time …

Background Recent studies have suggested that excessive formation of neutrophil
extracellular traps (NETs) plays a critical role in the pathogenesis of sepsis. Although …