Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: Perspectives for the treatment of Parkinson's disease
F Trotta, F Caldera, R Cavalli, M Soster… - Expert Opinion on …, 2016 - Taylor & Francis
Background: L-DOPA is an amino acid precursor to the neurotransmitter dopamine that is
extensively used as a prodrug for the treatment of Parkinson's disease. However, L-DOPA is …
extensively used as a prodrug for the treatment of Parkinson's disease. However, L-DOPA is …
The blood-brain barrier and nasal drug delivery to the central nervous system
MM Miyake, BS Bleier - American journal of rhinology & …, 2015 - journals.sagepub.com
Background The blood-brain barrier (BBB) is a highly efficient system that separates the
central nervous system (CNS) from general circulation and promotes selective transport of …
central nervous system (CNS) from general circulation and promotes selective transport of …
Protective effects of polysaccharides in neurodegenerative diseases
Y Wang, R Chen, Z Yang, Q Wen, X Cao… - Frontiers in Aging …, 2022 - frontiersin.org
Neurodegenerative diseases (NDs) are characterized by progressive degeneration and
necrosis of neurons, including Alzheimer's disease (AD), Parkinson's disease (PD) …
necrosis of neurons, including Alzheimer's disease (AD), Parkinson's disease (PD) …
Oral administration of nano-emulsion curcumin in mice suppresses inflammatory-induced NFκB signaling and macrophage migration
Despite the widespread use of curcumin for centuries in Eastern medicine as an anti-
inflammatory agent, its molecular actions and therapeutic viability have only recently been …
inflammatory agent, its molecular actions and therapeutic viability have only recently been …
Quality by Design approach for an in situ gelling microemulsion of Lorazepam via intranasal route
The present study illustrates the application of the concept of Quality by Design for
development, optimization and evaluation of Lorazepam loaded microemulsion containing …
development, optimization and evaluation of Lorazepam loaded microemulsion containing …
Fabrication of electrospun levodopa-carbidopa fixed-dose combinations
H Bukhary, GR Williams, M Orlu - Advanced Fiber Materials, 2020 - Springer
We report in this work coaxial electrospun fibers with potential applications in the treatment
of Parkinson's disease. The fibers comprise a fixed dose combination (FDC) containing the …
of Parkinson's disease. The fibers comprise a fixed dose combination (FDC) containing the …
Dendrimers as novel systems for delivery of neuropharmaceuticals to the brain
Most of the newly developed drugs fails to achieve sufficient bioavailability in to brain due to
low water solubility and low permeability. Drug delivery systems are one method for …
low water solubility and low permeability. Drug delivery systems are one method for …
[PDF][PDF] 普拉克索治疗帕金森病运动并发症的临床疗效观察
龙武， 杨期明， 蒋柏菊， 杨剑文， 杨骄， 雷涛… - 国际神经病学神经外 …, 2013 - jinn.org.cn
摘8 要目的8 评估普拉克索治疗帕金森病运动并发症的临床疗效及安全性$ 方法8 收集'!
例晚期帕金森病患者并随机分为治疗组和对照组# 每组;) 例$ 对照组给予多巴丝肼治疗# …
例晚期帕金森病患者并随机分为治疗组和对照组# 每组;) 例$ 对照组给予多巴丝肼治疗# …
Preparation and detailed characterization of the thiomer chitosan–cysteine as a suitable mucoadhesive excipient for nasal powders
The therapeutic application of nasal powders requires the development of novel
mucoadhesive excipients. Thiolated polymers exhibit significant potential for this purpose …
mucoadhesive excipients. Thiolated polymers exhibit significant potential for this purpose …
Development of poly (butylene succinate) microspheres for delivery of levodopa in the treatment of Parkinson's disease
K Mohanraj, S Sethuraman… - Journal of Biomedical …, 2013 - Wiley Online Library
Parkinson's is a major neurodegenerative disorder that occurs due to loss of dopaminergic
neurons in basal ganglia. Conventional therapy includes surgery that involves lot of risk and …
neurons in basal ganglia. Conventional therapy includes surgery that involves lot of risk and …