Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important
component of the extracellular matrix. This leads to the remodelling of the extracellular …

Proteome analysis implies the ability to separate proteins as a first step prior to
characterization. Thus, the overall performance of the analysis strongly depends on the …

Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular
matrix in all the animal species. This review will focus on the structural characteristics of the …

The role of mechanical properties in cancer disease and inflammation is still
underinvestigated and even ignored in many oncological and immunological reviews. In …

Integrins have been implicated as coreceptors in the infectious pathways of several
nonenveloped viruses. For example, adenoviruses are known to interact with αV integrins by …

Adsorption and plaque formation of foot-and-mouth disease virus (FMDV) serotype A12 are
inhibited by antibodies to the integrin αvβ3 (A. Berinstein et al., J. Virol. 69: 2664–2666 …

During placental malaria, Plasmodium falciparum infected erythrocytes sequester in the
placenta, causing health problems for both the mother and fetus. The specific adherence is …

By studying Loxosceles intermedia (Brown spider) venom we were able to detect a
proteolytic action on fibronectin and fibrinogen but an inability to degrade full length laminin …

The ability of chondroitin/dermatan sulfate (CS/DS) to convey biological information is
enriched by the presence of iduronic acid. DS-epimerases 1 and 2 (DS-epi1 and 2), in …

Many tumors express proteoglycans modified with oncofetal chondroitin sulfate
glycosaminoglycan chains (ofCS), which are normally restricted to the placenta. However …