Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

Natural killer (NK) cells constitute our bodies' frontline defense system, guarding against
tumors and launching attacks against infections. The activities of NK cells are regulated by …

Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …

The development of type 1 diabetes involves a complex interaction between pancreatic β-
cells and cells of both the innate and adaptive immune systems. Analyses of the interactions …

Abstract Type 1 diabetes (T1D) in children results from autoimmune destruction of
pancreatic beta cells, leading to insufficient production of insulin. A number of genetic …

The pathogenesis of autoimmunity remains to be fully elucidated, although the contribution
of genetic and environmental factors is generally recognized. Despite autoimmune …

Patients with Type 2 diabetes (T2D) are highly susceptible to infection and have an
increased incidence of some tumors, possibly due to immune system dysfunction. In the …

An association between diabetes and infection has been recognised for many years, with
infection being an important cause of death and morbidity in people with diabetes. The …

The mechanism of action of natural killer (NK) cells in type 1 diabetes is still unknown. Here
we show that the activating receptor NKp46 recognizes mouse and human ligands on …