Cancer cells can organize and communicate in functional networks. Similarly to other
networks in biology and sociology, these can be highly relevant for growth and resilience. In …

With increasing attention on the essential roles of the tumour microenvironment in recent
years, the nervous system has emerged as a novel and crucial facilitator of cancer growth. In …

Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …

The biological and pathological importance of mutual interactions between the nervous
system and cancer have become increasingly evident. The emerging field of cancer …

Background Glioblastoma is the most frequent and a particularly malignant primary brain
tumor with no efficacy-proven standard therapy for recurrence. It has recently been …

Diffuse gliomas are primary brain tumors associated with a poor prognosis. Cellular and
molecular mechanisms driving the invasive growth patterns and therapeutic resistance are …

Simple Summary Glioblastoma (GBM) is the most aggressive brain tumour. Patients with
GBM have a dismal survival and there is a distinct lack of curative treatments. We are …

Nervous system activity regulates development, homeostasis, and plasticity of the brain as
well as other organs in the body. These mechanisms are subverted in cancer to propel …

In this review, we discuss the use of the alkylating agent temozolomide (TMZ) in the
treatment of IDH-mutant gliomas. We describe the challenges associated with TMZ in clinical …

Background Glioblastoma is the most frequent and malignant primary brain tumor. Even in
the subgroup with O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation …