Ever since the world‐shaping discovery of penicillin, nature's molecular diversity has been
extensively screened for new medications and lead compounds in drug discovery. The …

The 1, 2-diamine moiety is an ubiquitous structural motif found in a wealth of natural
products, including non-proteinogenic amino acids and alkaloids, in pharmaceutical agents …

The fluoroquinolones are an important family of synthetic antimicrobial agents being
clinically used over the past thirty years. In addition, some fluoroquinolones have been used …

Approximately every minute, somewhere in the world four people die from tuberculosis (TB),
an infection of Mycobacterium tuberculosis with about 3 million deaths per year. In spite of …

Antibiotic resistance has been growing at an alarming rate and consequently the arsenal of
effective antibiotics against Gram-negative and Gram-positive bacteria has dropped …

Five new mixed ligand metal complexes were synthesized by the reaction of Zn (II), Zr (IV),
Ce (III), Th (IV) and U (VI) with ofloxacin (HOfl) and 2, 2′-bipyridine (Bipy) in presence of …

Nine new mononuclear Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II), Zn (II), Th (IV) and UO2
(VI) complexes of lomefloxacin drug were synthesized. The structures of these complexes …

A novel methodology has been developed for simultaneous separation of ciprofloxacin
(CPFLX), gatifloxacin (GTFLX), levofloxacin (LVFLX), moxifloxacin (MFLX) and sparfloxacin …

Tuberculosis (TB) is an important public health problem worldwilde due to AIDS epidemic,
the advent of multidrug resistant strains (MDR) and the lack of new drugs in the market. TB is …

Since their discovery over 5 decades ago, quinolone antibiotics have found enormous
success as broad spectrum agents that exert their activity through dual inhibition of bacterial …