Diabetes mellitus has emerged as a common comorbidity in cystic fibrosis and is considered
a clinical entity (cystic fibrosis-related diabetes, CFRD) distinct from that of type 1 diabetes …

Cystic fibrosis (CF) is the most common autosomal recessive disorder in Caucasian
populations. Individuals with CF have seen significant increases in life expectancy in the last …

Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity associated with
cystic fibrosis (CF).[A]• The pathophysiology of CFRD is complex and includes the loss of …

Rationale: Diabetes is associated with increased mortality in cystic fibrosis. Aggressive
screening and early institution of insulin treatment significantly reduced this risk over the …

Objective To determine whether the cystic fibrosis (CF) transmembrane conductance
regulator (CFTR) is involved in human insulin secretion by assessing the metabolic impact …

The cause of insulin insufficiency remains unknown in many diabetic cases. Up to 50% adult
patients with cystic fibrosis (CF), a disease caused by mutations in the gene encoding the …

Diabetes is a common age-dependent complication of cystic fibrosis (CF) that is strongly
influenced by modifier genes. We conducted a genome-wide association study in 3,059 …

Pancreatic α-cells are the major source of glucagon, a hormone that counteracts the
hypoglycemic action of insulin and strongly contributes to the correction of acute …

Rationale: Diabetes is associated with worse cystic fibrosis (CF) outcomes. The CFTR
potentiator ivacaftor is suggested to improve glucose homeostasis in individuals with CF …

Background Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR)
gene lead to the disease cystic fibrosis (CF). Although patients with CF often have …