Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
PT Nelson, DW Dickson, JQ Trojanowski, CR Jack… - Brain, 2019 - academic.oup.com
We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
Brain arteriolosclerosis
Abstract Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …
Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: Combined data from 13 community-based or population …
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …
Molecular characterization of selectively vulnerable neurons in Alzheimer's disease
K Leng, E Li, R Eser, A Piergies, R Sit, M Tan… - Nature …, 2021 - nature.com
Alzheimer's disease (AD) is characterized by the selective vulnerability of specific neuronal
populations, the molecular signatures of which are largely unknown. To identify and …
populations, the molecular signatures of which are largely unknown. To identify and …
Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease
Co-pathologies play an important role in the expression of the Alzheimer's disease clinical
phenotype and may influence treatment efficacy. Early-onset Alzheimer's disease, defined …
phenotype and may influence treatment efficacy. Early-onset Alzheimer's disease, defined …
Is Alzheimer disease a disease?
AD Korczyn, LT Grinberg - Nature Reviews Neurology, 2024 - nature.com
Dementia, a prevalent condition among older individuals, has profound societal
implications. Extensive research has resulted in no cure for what is perceived as the most …
implications. Extensive research has resulted in no cure for what is perceived as the most …
Prevalence and clinical phenotype of quadruple misfolded proteins in older adults
Importance Quadruple misfolded proteins (tau neurofibrillary tangles, amyloid-β [Aβ], α-
synuclein, and transactive response DNA-binding protein 43 [TDP-43]) in the same brain are …
synuclein, and transactive response DNA-binding protein 43 [TDP-43]) in the same brain are …
Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample
Dementia is more prevalent in Blacks than in Whites, likely due to a combination of
environmental and biological factors. Paradoxically, clinical studies suggest an attenuation …
environmental and biological factors. Paradoxically, clinical studies suggest an attenuation …
Vascular cognitive impairment and dementia
EC Wong, HC Chui - CONTINUUM: Lifelong Learning in …, 2022 - journals.lww.com
PURPOSE OF REVIEW This article gives a broad overview of vascular cognitive impairment
and dementia, including epidemiology, pathophysiology, clinical approach, and …
and dementia, including epidemiology, pathophysiology, clinical approach, and …
Combined neuropathological pathways account for age‐related risk of dementia
Objective Our objectives were to characterize the inter‐relation of known dementia‐related
neuropathologies in one comprehensive model and quantify the extent to which …
neuropathologies in one comprehensive model and quantify the extent to which …