Nucleotide excision repair (NER) eliminates various structurally unrelated DNA lesions by a
multiwise'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway …

Over the past few years, media have popularized the story of the “children of the moon” who
must remain in the dark and avoid exposure to sunlight. 1r3 These children suffer from a rare …

The WD40-repeat protein DDB2 is essential for efficient recognition and subsequent
removal of ultraviolet (UV)-induced DNA lesions by nucleotide excision repair (NER) …

Publisher Summary DNA damage is a common occurrence that compromises the functional
integrity of DNA. It is not surprising then that cells have multiple mechanisms for coping with …

Each day a cell must face a constant onslaught of DNA lesions. Although we tend to worry
most about environmental sources of DNA damage (eg, chemical agents, UV radiation …

Nucleotide excision repair (NER) is a major DNA repair pathway that ensures that the
genome remains functionally intact and is faithfully transmitted to progeny. However, defects …

Damaged DNA-binding protein, DDB, is a heterodimer of p127 and p48 with a high
specificity for binding to several types of DNA damage. Mutations in the p48 gene that cause …

For faithful DNA repair, it is crucial for cells to locate lesions precisely within the vast
genome. In the mammalian global genomic nucleotide excision repair (NER) pathway, this …

One of the longest standing problems in DNA repair is how cells relax chromatin in order to
make DNA lesions accessible for global nucleotide excision repair (NER). Since chromatin …

The cyclobutane thymine dimer is the major DNA lesion induced in human skin by sunlight
and is a primary cause of skin cancer, the most prevalent form of cancer in the Northern …